Indeed, LINE-1 is the only active, autonomous retrotransposon in humans and its retrotransposition continues to generate both intra-individual and inter-individual genetic diversity. Although the vast majority of human LINE-1 sequences are inactive molecular fossils, an estimated 80-100 copies per individual retain the ability to mobilize by a process termed retrotransposition.
The retrotransposon Long INterspersed Element-1 (LINE-1 or L1), by virtue of its replicative mobilization mechanism, comprises âˆ❁7% of the human genome. Transposable elements have had a profound impact on the structure and function of mammalian genomes. Richardson, Sandra R Doucet, Aurélien J Kopera, Huira C Moldovan, John B Garcia-Perez, José Luis Moran, John V The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.
